Paraoxonase and Coronary Heart Disease Risk Language
نویسنده
چکیده
Organophosphates were first synthesized in the 1930s as insecticides1 and were subsequently shown to have direct neurotoxic effects in mammals, as well. The neurotoxicity is derived from their ability to inhibit acetylcholinesterase by covalently modifying the active-site serine group in the enzyme. Mazur2 first demonstrated the presence of an organophosphate-hydrolyzing enzyme in mammalian tissue, an observation that ultimately led to the identification of a human paraoxonase in serum in 1953.3 Paraoxonase—so named because of its ability to hydrolyze the toxic metabolite of parathion, paraoxon—was also shown early after its identification to manifest arylesterase activity, an effect that was underappreciated until the enzyme was found to play a role in modulating vascular oxidant stress many years later.
منابع مشابه
Paraoxonase 1 Activity, Lipid Profile, and Atherogenic Indexes Status in Coronary Heart Disease
Background: Dyslipidemia is considered an independent risk factor for coronary heart disease (CHD). In the present study, we examined lipid profiles and paraoxonase 1 (PON1) activity and atherogenic indexes status and the relationship of PON1 activity by high-density lipoprotein (HDL) and atherogenic indexes in CHD patients and healthy people. Methods: The aim of the study was to compare PON...
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Paraoxonase can hydrolyse organophosphate esters and paraxon is its most important substrate in laboratory studies. This enzyme circulates in blood with HDL. It seems that reduced paraoxonase activity in human may increase risk of coronary artery disease. Genetic variations in two autosomal genes may reduce its activity. These variations produce three phenotypes: A, AB and B. B phenotype ac...
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